Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 9/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | FPR1 | P21462 | 3/20 | 0.34 |
| ▸ | SCN1A | P35498 | 4/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.33 |
| ▸ | SCN1B | Q07699 | 2/20 | 0.33 |
| ▸ | CYP2C18 | P33260 | 4/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5732239 | 0.81 | CYP2C9 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3318402 | 0.81 | CYP2C9 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3317868 | 0.81 | PSEN1 (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3318127 | 0.80 | PSEN1 (0.64) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3319355 | 0.80 | PSEN1 (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3319675 | 0.76 | PSEN1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3316928 | 0.74 | EEF2K (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3316420 | 0.72 | PSEN1 (0.75) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3316953 | 0.71 | PSEN1 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3322223 | 0.70 | PSEN1 (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1910158-A | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole | WYETH CORP (US) | 2007-02-07 | — | — | CN | claimed |
| CN-1910158-A | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole | WYETH CORP (US) | 2007-02-07 | — | — | CN | disclosed |