Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 4/20 | 0.36 |
| ▸ | IGF1R | P08069 | 12/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27678730 | 0.88 | TNK2 (0.46) | TNK2IGF1RCYP3A4MAPK3MAPK1 | |
| SCHEMBL6938221 | 0.86 | TNK2 (0.37) | TNK2IGF1RCYP3A4MAPK3MAPK1 | |
| SCHEMBL402204 | 0.86 | TNK2 (0.37) | TNK2IGF1RCYP3A4MAPK3MAPK1 | |
| SCHEMBL2964083 | 0.84 | TNK2 (0.48) | TNK2IGF1RCYP3A4MAPK3MAPK1 | |
| SCHEMBL397202 | 0.84 | TNK2 (0.48) | TNK2IGF1RCYP3A4MAPK3MAPK1 | |
| Methylpiperazine SCHEMBL1131232 | 0.81 | TNK2 (0.44) | TNK2IGF1RCYP3A4MAPK3MAPK1 | |
| SCHEMBL13812631 | 0.75 | TNK2 (0.42) | TNK2 | |
| SCHEMBL398540 | 0.75 | TNK2 (0.42) | TNK2IGF1R | |
| SCHEMBL1129050 | 0.75 | TNK2 (0.42) | TNK2IGF1R | |
| SCHEMBL19264064 | 0.75 | TNK2 (0.38) | TNK2IGF1RCYP3A4MAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1960993-A | 6, 6-bicyclic substituted heterobicyclic protein kinase inhibitors | OSI PHARM INC (US) | 2007-05-09 | — | — | CN | disclosed |