Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.61 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.57 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.43 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL392127 | 0.86 | MAP2K1 (0.81) | MAP2K1MAP2K2 | |
| SCHEMBL27679442 | 0.85 | MAP2K1 (0.78) | MAP2K1MAP2K2 | |
| SCHEMBL27659369 | 0.84 | MAP2K1 (0.63) | MAP2K1MAP2K2 | |
| SCHEMBL14549012 | 0.82 | MAP2K1 (0.80) | MAP2K1MAP2K2 | |
| SCHEMBL5622965 | 0.82 | MAP2K1 (0.82) | MAP2K1MAP2K2BAZ2BBAZ2A | |
| SCHEMBL27883692 | 0.80 | MAP2K1 (0.59) | MAP2K1MAP2K2 | |
| SCHEMBL27867329 | 0.80 | MAP2K1 (0.76) | MAP2K1MAP2K2 | |
| SCHEMBL6526634 | 0.78 | MAP2K1 (0.76) | MAP2K1MAP2K2BAZ2BBAZ2A | |
| SCHEMBL392922 | 0.78 | MAP2K1 (0.83) | MAP2K1MAP2K2 | |
| SCHEMBL393588 | 0.77 | MAP2K1 (0.49) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1905873-A | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA INC (US) | 2007-01-31 | — | — | CN | disclosed |