Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.58 |
| ▸ | KAT8 | Q9H7Z6 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31512218 | 0.89 | BTK (0.58) | BTKKAT8KMT2AL3MBTL1EPHX1 | |
| SCHEMBL12424258 | 0.89 | BTK (0.64) | BTKKAT8KMT2AL3MBTL1EPHX1 | |
| SCHEMBL20689413 | 0.89 | BTK (0.64) | BTKKAT8KMT2AL3MBTL1EPHX1 | |
| SCHEMBL15284092 | 0.84 | BTK (0.56) | BTKKAT8KMT2AL3MBTL1EPHX1 | |
| SCHEMBL24448978 | 0.83 | BTK (0.64) | BTKKAT8KMT2AL3MBTL1EPHX1 | |
| SCHEMBL24449601 | 0.83 | BTK (0.64) | BTKKAT8KMT2AL3MBTL1EPHX1 | |
| SCHEMBL2377443 | 0.83 | BTK (0.64) | BTKKAT8KMT2AL3MBTL1EPHX1 | |
| SCHEMBL25319683 | 0.83 | BTK (0.64) | BTKKAT8KMT2AL3MBTL1EPHX1 | |
| SCHEMBL21027650 | 0.83 | BTK (0.64) | BTKKAT8KMT2AL3MBTL1EPHX1 | |
| SCHEMBL24448965 | 0.83 | BTK (0.64) | BTKKAT8KMT2AL3MBTL1EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1871215-B | Cyclic derivatives as modulators of chemokine receptor activity | BRISTOL MYERS SQUIBB CO | 2011-06-08 | — | — | CN | disclosed |
| CN-1871215-A | Cyclic derivatives as modulators of chemokine receptor activity | BRISTOL MYERS SQUIBB CO (US) | 2006-11-29 | — | — | CN | disclosed |