Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 20/20 | 0.74 |
| ▸ | CHUK | O15111 | 2/20 | 0.63 |
| ▸ | RET | P07949 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.63 |
| ▸ | FLT4 | P35916 | 1/20 | 0.63 |
| ▸ | KDR | P35968 | 1/20 | 0.63 |
| ▸ | EPHB1 | P54762 | 1/20 | 0.63 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2766958 | 0.95 | IKBKB (0.72) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL2784712 | 0.94 | IKBKB (0.68) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL2766154 | 0.92 | IKBKB (0.71) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL2769117 | 0.91 | IKBKB (0.77) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL2768020 | 0.91 | IKBKB (0.77) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL3036740 | 0.91 | IKBKB (0.65) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL2766987 | 0.90 | IKBKB (0.61) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL2769002 | 0.90 | IKBKB (0.80) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL2767917 | 0.89 | IKBKB (0.66) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL2768883 | 0.89 | IKBKB (0.67) | IKBKBCHUKRETCYP2C9EPHA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888584-B1 | 1, 6 -DIHYDRO- 1,3, 5, 6-TETRAAZA-AS-INDACENE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AS INHIBITORS OF IKK ENZYME ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2010-04-21 | — | — | EP | disclosed |