Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | RHEB | Q15382 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL914286 | 0.84 | PARP1 (0.54) | HRH4 | |
| SCHEMBL914665 | 0.83 | HRH4 (0.48) | HRH4RHEB | |
| SCHEMBL914907 | 0.83 | KDM4E (0.49) | HRH4RHEB | |
| SCHEMBL916158 | 0.83 | KDM4E (0.49) | HRH4RHEB | |
| SCHEMBL28762593 | 0.79 | KMT2A (0.44) | HRH4POLBRHEBGRIN2DGRIN3B | |
| SCHEMBL17098873 | 0.78 | HRH4 (0.43) | HRH4FLT3 | |
| SCHEMBL3281633 | 0.77 | POLB (0.43) | POLB | |
| SCHEMBL6966095 | 0.77 | HRH4 (0.43) | HRH4RHEB | |
| SCHEMBL914210 | 0.77 | HRH4 (0.43) | HRH4RHEB | |
| SCHEMBL27653275 | 0.75 | SRD5A2 (0.47) | POLBRHEBGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102391251-A | Chemokine receptor antagonists | NOVARTIS AG | 2012-03-28 | — | — | CN | disclosed |
| CN-1946713-A | Chemokine receptor antagonists | NOVARTIS AG (CH) | 2007-04-11 | — | — | CN | disclosed |