Safrole

Safrole

SCHEMBL27675446

C=CCc1ccc2c(c1)OCO2.[H+]

nearest known ligand 0.96

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Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 6/20 0.96
CYP1A2 P05177 2/20 0.96
MAPT P10636 1/20 0.96
TAAR1 Q96RJ0 4/20 0.53
SLC6A4 P31645 3/20 0.51
ALDH1A1 P00352 3/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
SLC6A2 P23975 2/20 0.49
SLC6A3 Q01959 2/20 0.49
CYP2D6 P10635 2/20 0.49
CMA1 P23946 1/20 0.49
GAA P10253 1/20 0.47
CYP2C19 P33261 1/20 0.47
MIF P14174 1/20 0.47
CALM1 P0DP23 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Safrole SCHEMBL29368306 0.98 CYP3A4 (1.00) CYP3A4CYP1A2MAPTTAAR1SLC6A4
Safrole SCHEMBL56828 0.98 CYP3A4 (1.00) CYP3A4CYP1A2MAPTTAAR1SLC6A4
Safrole SCHEMBL2039562 0.98 CYP3A4 (1.00) CYP3A4CYP1A2MAPTTAAR1SLC6A4
Safrole SCHEMBL27814983 0.96 CYP3A4 (0.96) CYP3A4CYP1A2MAPTTAAR1SLC6A4
Safrole SCHEMBL28606225 0.96 CYP3A4 (0.96) CYP3A4CYP1A2MAPTTAAR1SLC6A4
Safrole SCHEMBL27722328 0.96 CYP3A4 (0.96) CYP3A4CYP1A2MAPTTAAR1SLC6A4
Safrole SCHEMBL28422104 0.93 CYP3A4 (0.90) CYP3A4CYP1A2MAPTTAAR1SLC6A4
Safrole SCHEMBL27566359 0.93 CYP3A4 (0.90) CYP3A4CYP1A2MAPTTAAR1SLC6A4
Safrole SCHEMBL28871644 0.90 CYP3A4 (0.84) CYP3A4CYP1A2MAPTTAAR1SLC6A4
Safrole SCHEMBL28246837 0.89 CYP3A4 (0.81) CYP3A4CYP1A2MAPTTAAR1SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106632228-B A kind of preparation method of dihydrosafrole 成都建中香料香精有限公司 2019-07-02 CN disclosed
CN-107815348-A A kind of method that safrole is removed in the oil from borneol 广州栋方生物科技股份有限公司 2018-03-20 CN disclosed
CN-106632228-A Preparation method of dihydrosafrole 成都建中香料香精有限公司 2017-05-10 CN disclosed
CN-1907980-A Method for synthesizing dihydrosafrole GUIYANG HAIFENG FINE CHEMICAL (CN) 2007-02-07 CN disclosed