Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 19/20 | 0.72 |
| ▸ | CHUK | O15111 | 13/20 | 0.72 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.54 |
| ▸ | FLT4 | P35916 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | EPHB1 | P54762 | 1/20 | 0.54 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3039541 | 0.93 | IKBKB (0.71) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL2767684 | 0.92 | IKBKB (0.72) | IKBKBCHUK | |
| SCHEMBL2767308 | 0.92 | IKBKB (0.70) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL2767788 | 0.91 | IKBKB (0.69) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL2767053 | 0.91 | IKBKB (0.76) | IKBKBCHUK | |
| SCHEMBL2765976 | 0.90 | IKBKB (0.73) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL2767444 | 0.90 | IKBKB (0.68) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL13376625 | 0.90 | IKBKB (0.71) | IKBKBCHUK | |
| SCHEMBL2769800 | 0.90 | IKBKB (0.71) | IKBKBCHUKRETCYP2C9EPHA1 | |
| SCHEMBL2768713 | 0.90 | IKBKB (0.67) | IKBKBCHUKRETCYP2C9EPHA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737279-B2 | 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-06-15 | — | — | US | claimed |
| EP-1888584-B1 | 1, 6 -DIHYDRO- 1,3, 5, 6-TETRAAZA-AS-INDACENE BASED TRICYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AS INHIBITORS OF IKK ENZYME ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2010-04-21 | — | — | EP | disclosed |