Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27659384 | 0.93 | MAP2K1 (0.51) | MAP2K1POLBMEN1HTTKMT2A | |
| SCHEMBL392685 | 0.86 | MAP2K1 (0.57) | MAP2K1POLBMEN1HTTKMT2A | |
| SCHEMBL388534 | 0.85 | MAP2K1 (0.57) | MAP2K1POLBMEN1HTTKMT2A | |
| SCHEMBL27679436 | 0.84 | MAP2K1 (0.68) | MAP2K1 | |
| SCHEMBL392162 | 0.83 | MAP2K1 (0.75) | MAP2K1 | |
| SCHEMBL5179043 | 0.81 | MAP2K1 (0.68) | MAP2K1MEN1KMT2A | |
| SCHEMBL390061 | 0.80 | MAP2K1 (0.74) | MAP2K1 | |
| SCHEMBL27659398 | 0.80 | MAP2K1 (0.57) | MAP2K1 | |
| SCHEMBL392481 | 0.80 | MAP2K1 (0.67) | MAP2K1POLBMEN1HTTKMT2A | |
| SCHEMBL27883684 | 0.79 | MAP2K1 (0.55) | MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1905873-A | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA INC (US) | 2007-01-31 | — | — | CN | disclosed |