Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.79 |
| ▸ | PTPRO | Q16827 | 1/20 | 0.79 |
| ▸ | STAT3 | P40763 | 4/20 | 0.44 |
| ▸ | RARB | P10826 | 3/20 | 0.41 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.40 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1734581 | 0.88 | PTPN11 (0.81) | PTPN11PTPROSTAT3RARBRARA | |
| SCHEMBL1733827 | 0.88 | PTPN11 (1.00) | PTPN11PTPROSTAT3RARBRARA | |
| Hydrochloric Acid SCHEMBL1815540 | 0.87 | PTPN11 (0.98) | PTPN11PTPROSTAT3RARBRARA | |
| SCHEMBL1733835 | 0.87 | PTPN11 (0.80) | PTPN11PTPROSTAT3RARBRARA | |
| SCHEMBL1734788 | 0.86 | PTPN11 (0.85) | PTPN11PTPROSTAT3RARBRARA | |
| SCHEMBL1736199 | 0.84 | PTPN11 (0.75) | PTPN11PTPROSTAT3RARBRARA | |
| SCHEMBL1734805 | 0.84 | PTPN11 (0.92) | PTPN11PTPROSTAT3RARBRARA | |
| SCHEMBL1735881 | 0.83 | PTPN11 (0.74) | PTPN11PTPROSTAT3RARBRARA | |
| SCHEMBL1734802 | 0.82 | PTPN11 (0.89) | PTPN11PTPROSTAT3BCL2L1MCL1 | |
| SCHEMBL1814311 | 0.81 | PTPN11 (0.70) | PTPN11PTPROSTAT3RARBRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1997638-B | 1,1' - (1, 2-acetylenediyl) bis-benzene derivatives as PTP1-B inhibitors | APPLIED RESEARCH SYSTEMS | 2011-07-06 | — | — | CN | disclosed |
| CN-1997638-A | 1, 1' - (1, 2-acetylenediyl) bis-benzene derivatives as PTP 1-B inhibitors | APPLIED RESEARCH SYSTEMS (AN) | 2007-07-11 | — | — | CN | disclosed |