Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CPB1 | P15086 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3525505 | 0.89 | USP7 (0.47) | — | |
| SCHEMBL27683018 | 0.88 | BTK (0.41) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL28766983 | 0.81 | LCK (0.38) | SMN1; SMN2MEN1HPGDKMT2AIDH1 | |
| SCHEMBL3518367 | 0.79 | MAPK14 (0.38) | KMT2AMAPK14HTR2AHTR2CSLC6A4 | |
| SCHEMBL5269614 | 0.79 | MAPK14 (0.41) | MAPK14HTR2AHTR2CSLC6A4BRD4 | |
| SCHEMBL3526294 | 0.79 | USP7 (0.51) | SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL3525831 | 0.78 | MAPK14 (0.38) | KMT2AMAPK14HTR2AHTR2CSLC6A4 | |
| Hydrochloric Acid SCHEMBL3521994 | 0.78 | MAPK14 (0.40) | MAPK14HTR2AHTR2CSLC6A4 | |
| SCHEMBL6470884 | 0.76 | MAPK14 (0.54) | MAPK14 | |
| SCHEMBL5264974 | 0.76 | SMN1; SMN2 (0.39) | SMN1; SMN2KMT2AALDH1A1LMNAMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1968937-A | Pyrimidin-4-one derivatives and their use as P38 kinase modulators | PHARMACIA CORP (US) | 2007-05-23 | — | — | CN | disclosed |