Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2882458 | 0.79 | HTT (0.41) | HTTLMNASMN1; SMN2ALOX15TSHR | |
| SCHEMBL2877338 | 0.77 | HPGD (0.57) | GAAHPGD | |
| SCHEMBL2877339 | 0.77 | HPGD (0.57) | GAAHPGD | |
| SCHEMBL9775011 | 0.69 | HTT (0.74) | HTTLMNASMN1; SMN2ALOX15TSHR | |
| SCHEMBL229982 | 0.67 | HTT (0.81) | HTTLMNASMN1; SMN2ALOX15TSHR | |
| SCHEMBL13993870 | 0.63 | HTT (0.68) | HTTLMNASMN1; SMN2KMT2AMAPT | |
| SCHEMBL1607500 | 0.62 | HDAC1 (0.58) | HTTKMT2A | |
| SCHEMBL5796531 | 0.62 | HTT (0.66) | HTTLMNASMN1; SMN2ALOX15TSHR | |
| SCHEMBL784573 | 0.61 | HTT (1.00) | HTTLMNASMN1; SMN2ALOX15TSHR | |
| SCHEMBL2950203 | 0.61 | HTT (0.56) | HTTLMNASMN1; SMN2ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101056633-A | PI3 kinase gamma inhibitors for the treatment of anemia | APPLIED RESEARCH SYSTEMS (AN) | 2007-10-17 | — | — | CN | claimed |
| CN-101300047-A | PI3K inhibitors for the treatment of endometriosis | SERONO LAB (CH) | 2008-11-05 | — | — | CN | disclosed |