SCHEMBL27686180

SCHEMBL27686180

NC(=O)c1c(C(CO)C(O)O)c2ncc(Cc3ccc(F)cc3)cc2[nH]c1=O

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 18/20 0.34
TDP1 Q9NUW8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27667063 0.87 GRM2 (0.34) GRM2TDP1
SCHEMBL27667206 0.83 SCN9A (0.36) GRM2TDP1
SCHEMBL5546423 0.81 TDP1 (0.40) GRM2TDP1
SCHEMBL27666982 0.81 BTK (0.34) GRM2TDP1
SCHEMBL27667075 0.81 GRM2 (0.33) GRM2TDP1
SCHEMBL28767160 0.81 GRM2 (0.35) GRM2TDP1
SCHEMBL27686099 0.81 TDP1 (0.32) GRM2TDP1
SCHEMBL27667170 0.80 BTK (0.33) GRM2TDP1
SCHEMBL27667160 0.79 GRM2 (0.34) GRM2TDP1
SCHEMBL27667070 0.79 NTRK1 (0.36) GRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1976915-A HIV integrase inhibitors SMITHKLINE BEECHAM CORP (US) 2007-06-06 CN disclosed