Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.58 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | CDK7 | P50613 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 17/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 15/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1749647 | 0.93 | IGF1R (0.57) | IGF1RLCKGSK3AGSK3BCDK7 | |
| SCHEMBL1749213 | 0.90 | IGF1R (0.54) | IGF1RLCKGSK3AGSK3BCDK7 | |
| SCHEMBL1749105 | 0.89 | IGF1R (0.51) | IGF1RLCKGSK3AGSK3BCDK7 | |
| SCHEMBL1749790 | 0.88 | IGF1R (0.56) | IGF1RLCKGSK3AGSK3BCDK7 | |
| Hydrochloric Acid SCHEMBL1749137 | 0.86 | IGF1R (0.53) | IGF1RLCKGSK3AGSK3BCDK7 | |
| SCHEMBL1749523 | 0.85 | IGF1R (0.64) | IGF1RLCKGSK3AGSK3BCDK7 | |
| SCHEMBL1748818 | 0.85 | IGF1R (0.64) | IGF1RLCKGSK3AGSK3BCDK7 | |
| SCHEMBL1748739 | 0.84 | IGF1R (0.57) | IGF1RLCKGSK3AGSK3BCDK7 | |
| SCHEMBL1749488 | 0.83 | IGF1R (0.55) | IGF1RLCKGSK3AGSK3BCDK7 | |
| SCHEMBL1748882 | 0.83 | IGF1R (0.54) | IGF1RLCKGSK3AGSK3BCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1950083-A | Novel pyrrolo (2,3-b)pyridine derivatives, the preparation and the pharmaceutical use thereof in the form of kinase inhibitors | AVENTIS PHARMA SA (FR) | 2007-04-18 | — | — | CN | disclosed |