Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 14/20 | 0.66 |
| ▸ | CHUK | O15111 | 10/20 | 0.66 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3802579 | 0.80 | IKBKB (1.00) | IKBKBCHUKPDPK1 | |
| SCHEMBL27698212 | 0.78 | CHEK1 (0.50) | IKBKBCHUKPDPK1CDC7ACMSD | |
| SCHEMBL4689422 | 0.78 | IKBKB (0.97) | IKBKBCHUKPDPK1 | |
| SCHEMBL4687705 | 0.77 | IKBKB (0.78) | IKBKBCHUKPDPK1CDC7ACMSD | |
| SCHEMBL4685346 | 0.77 | IKBKB (1.00) | IKBKBCHUKPDPK1BTK | |
| SCHEMBL4685618 | 0.77 | IKBKB (0.74) | IKBKBCHUKPDPK1CDC7 | |
| SCHEMBL27709861 | 0.77 | IKBKB (0.64) | IKBKBCHUKPDPK1CDC7BTK | |
| SCHEMBL4690245 | 0.76 | IKBKB (0.76) | IKBKBCHUKPDPK1ALDH1A1 | |
| SCHEMBL4686157 | 0.76 | IKBKB (0.76) | IKBKBCHUKPDPK1CHEK2 | |
| SCHEMBL4687592 | 0.76 | IKBKB (1.00) | IKBKBCHUKPDPK1CDC7BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101677547-A | Indole carboxamides as the IKK2 inhibitor | SMITHKLINE BEECHAM CORP | 2010-03-24 | — | — | CN | disclosed |
| CN-101060842-A | Chemical compounds | GLAXO GROUP LTD (GB) | 2007-10-24 | — | — | CN | disclosed |