Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.68 |
| ▸ | MTOR | P42345 | 3/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.43 |
| ▸ | ATR | Q13535 | 2/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | USP1 | O94782 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4167630 | 1.00 | FYN (0.68) | FYNMTORGRIN1GRIN2BJAK2 | |
| SCHEMBL481843 | 0.89 | FYN (0.60) | FYNMTORJAK2JAK3MAP3K11 | |
| SCHEMBL481842 | 0.89 | FYN (0.60) | FYNMTORJAK2JAK3MAP3K11 | |
| SCHEMBL975509 | 0.86 | FYN (0.72) | FYNMTORJAK2JAK3MAP3K11 | |
| SCHEMBL481671 | 0.85 | FYN (0.71) | FYNMTORGRIN1GRIN2BJAK2 | |
| SCHEMBL481669 | 0.85 | FYN (0.71) | FYNMTORJAK2JAK3MAP3K11 | |
| SCHEMBL481394 | 0.83 | FYN (0.75) | FYNMTORGRIN1GRIN2BJAK2 | |
| SCHEMBL481311 | 0.82 | FYN (0.68) | FYNMTORMAP3K11ATRPRKDC | |
| SCHEMBL4270853 | 0.82 | FYN (0.70) | FYNMTORGRIN1GRIN2BMAP3K11 | |
| SCHEMBL481854 | 0.81 | FYN (0.66) | FYNMTORJAK2MAP3K11ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101065016-A | Imidazo{4,5-b}pyrazinone inhibitors of protein kinases | JANSSEN PHARMACEUTICA NV (BE) | 2007-10-31 | — | — | CN | claimed |
| CN-101065016-A | Imidazo{4,5-b}pyrazinone inhibitors of protein kinases | JANSSEN PHARMACEUTICA NV (BE) | 2007-10-31 | — | — | CN | disclosed |