Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30548021 | 0.79 | MAP2K1 (0.65) | MAP2K1CYP1A2TSHRMAPK1LRRK2 | |
| SCHEMBL25249427 | 0.79 | MAP2K1 (0.65) | MAP2K1CYP1A2TSHRMAPK1LRRK2 | |
| SCHEMBL186113 | 0.79 | MAP2K1 (1.00) | MAP2K1LRRK2AURKAAURKBPLK4 | |
| SCHEMBL14631605 | 0.79 | MAP2K1 (0.65) | MAP2K1CYP1A2TSHRMAPK1MAP2K4 | |
| SCHEMBL19780200 | 0.75 | MAP2K1 (0.37) | MAP2K1LRRK2AURKAAURKBPLK4 | |
| SCHEMBL8404437 | 0.75 | MAPK1 (0.54) | MAP2K1CYP1A2TSHRMAPK1MAP2K4 | |
| SCHEMBL4416040 | 0.75 | MAP2K1 (0.59) | MAP2K1CYP1A2TSHRMAPK1LRRK2 | |
| SCHEMBL29950691 | 0.75 | MAP2K1 (0.59) | MAP2K1CYP1A2TSHRMAPK1LRRK2 | |
| SCHEMBL5530390 | 0.73 | MAP2K1 (0.49) | MAP2K1CYP1A2MAPK1GAA | |
| SCHEMBL7737948 | 0.72 | CYP1A2 (0.43) | MAP2K1CYP1A2TSHRMAPK1MAP2K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101146796-A | 3-(indazol-5-yl)-(1,2,4)triazine derivatives and related compounds as protein kinase inhibitors for the treatment of cancer | SCHERING CORP (US) | 2008-03-19 | — | — | CN | disclosed |