Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.42 |
| ▸ | INCENP | Q9NQS7 | 8/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | STK10 | O94804 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | FER | P16591 | 1/20 | 0.41 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.41 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | TEC | P42680 | 1/20 | 0.41 |
| ▸ | ABL2 | P42684 | 1/20 | 0.41 |
| ▸ | FRK | P42685 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3536533 | 0.95 | AURKA (0.54) | AURKAAURKBINCENPPLK4JAK2 | |
| SCHEMBL3476153 | 0.91 | AURKA (0.56) | AURKAAURKBINCENPPLK4JAK2 | |
| Hydrochloric Acid SCHEMBL3535629 | 0.90 | AURKA (0.55) | AURKAAURKBINCENPPLK4JAK2 | |
| SCHEMBL29720370 | 0.90 | AURKA (0.58) | AURKAAURKBINCENPPLK4JAK2 | |
| SCHEMBL1704218 | 0.90 | AURKA (0.58) | AURKAAURKBINCENPPLK4JAK2 | |
| SCHEMBL29443431 | 0.90 | AURKA (0.58) | AURKAAURKBINCENPPLK4JAK2 | |
| SCHEMBL3535741 | 0.90 | AURKA (0.54) | AURKAAURKBINCENPPLK4JAK2 | |
| Hydrochloric Acid SCHEMBL3529855 | 0.89 | AURKA (0.57) | AURKAAURKBINCENPPLK4JAK2 | |
| SCHEMBL3528885 | 0.88 | AURKA (0.53) | AURKAAURKBINCENPPLK4JAK2 | |
| SCHEMBL27718228 | 0.88 | AURKA (0.71) | AURKAAURKBINCENPPLK4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101103017-A | Novel aminopyridine derivatives having Aurora-A selective inhibitory action | BANYU PHARMA CO LTD (JP) | 2008-01-09 | — | — | CN | disclosed |