Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.88 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | FABP1 | P07148 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | LIFR | P42702 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2769788 | 1.00 | NR1H4 (0.88) | NR1H4MEN1FABP1THRBLIFR | |
| SCHEMBL2771713 | 0.91 | NR1H4 (0.72) | NR1H4MEN1FABP1THRBLIFR | |
| SCHEMBL2771715 | 0.91 | NR1H4 (0.72) | NR1H4MEN1FABP1THRBLIFR | |
| SCHEMBL2773683 | 0.91 | NR1H4 (0.72) | NR1H4MEN1FABP1THRBLIFR | |
| SCHEMBL2773684 | 0.91 | NR1H4 (0.72) | NR1H4MEN1FABP1THRBLIFR | |
| SCHEMBL10157975 | 0.86 | NR1H4 (0.88) | NR1H4MEN1FABP1THRBLIFR | |
| SCHEMBL2771761 | 0.84 | NR1H4 (0.64) | NR1H4MEN1FABP1THRBLIFR | |
| SCHEMBL2771763 | 0.84 | NR1H4 (0.64) | NR1H4MEN1FABP1THRBLIFR | |
| SCHEMBL2770317 | 0.84 | NR1H4 (0.68) | NR1H4LIFR | |
| SCHEMBL2770495 | 0.84 | NR1H4 (0.67) | NR1H4LIFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |