Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | MARK3 | P27448 | 1/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | FECH | P22830 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL304858 | 0.82 | CHEK1 (0.53) | CHEK1CHEK2AURKAMARK3PRKCD | |
| SCHEMBL27697947 | 0.76 | CHEK1 (0.51) | CHEK1CHEK2AURKAMARK3PRKCD | |
| SCHEMBL306549 | 0.76 | CHEK1 (0.51) | CHEK1CHEK2AURKAMARK3PRKCD | |
| SCHEMBL5190190 | 0.76 | CHEK1 (0.51) | CHEK1CHEK2AURKAMARK3PRKCD | |
| SCHEMBL304759 | 0.74 | CHEK1 (0.74) | CHEK1CHEK2AURKAMARK3PRKCD | |
| SCHEMBL304760 | 0.74 | CHEK1 (0.74) | CHEK1CHEK2AURKAMARK3PRKCD | |
| SCHEMBL305349 | 0.74 | CHEK1 (0.74) | CHEK1CHEK2AURKAMARK3PRKCD | |
| SCHEMBL305619 | 0.73 | CHEK1 (0.52) | CHEK1CHEK2AURKAMARK3PRKCD | |
| SCHEMBL305231 | 0.73 | CHEK1 (0.52) | CHEK1CHEK2AURKAMARK3PRKCD | |
| SCHEMBL305230 | 0.73 | CHEK1 (0.52) | CHEK1CHEK2AURKAMARK3PRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102219784-A | Heteroaryl urea derivatives useful for inhibition of CHK1 | ICOS CORP | 2011-10-19 | — | — | CN | disclosed |
| CN-101151259-B | Heteroaryl urea derivatives useful for inhibition of CHK1 | ICOS CORP | 2011-06-15 | — | — | CN | disclosed |
| CN-101151259-A | Heteroaryl urea derivatives useful for inhibition of CHKI | ICOS CORP (US) | 2008-03-26 | — | — | CN | disclosed |