Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.79 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.69 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.69 |
| ▸ | GAK | O14976 | 1/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2248340 | 1.00 | EGFR (0.79) | EGFRERBB2ERBB4GAKHDAC3 | |
| SCHEMBL2249186 | 0.90 | EGFR (0.81) | EGFRERBB2ERBB4GAKHDAC3 | |
| SCHEMBL2248342 | 0.89 | EGFR (0.80) | EGFRERBB2ERBB4GAKHDAC3 | |
| SCHEMBL2249387 | 0.89 | EGFR (0.85) | EGFRERBB2ERBB4GAKHDAC2 | |
| SCHEMBL2249385 | 0.89 | EGFR (0.85) | EGFRERBB2ERBB4GAKHDAC2 | |
| SCHEMBL2248427 | 0.86 | EGFR (0.72) | EGFRERBB2ERBB4HDAC3HDAC4 | |
| SCHEMBL2255059 | 0.84 | EGFR (0.87) | EGFRERBB2ERBB4GAKHDAC3 | |
| SCHEMBL4865102 | 0.84 | EGFR (0.75) | EGFRERBB2ERBB4GAKHDAC3 | |
| SCHEMBL20412221 | 0.84 | EGFR (0.82) | EGFRERBB2ERBB4GAKHDAC3 | |
| SCHEMBL2249817 | 0.84 | EGFR (0.78) | EGFRERBB2ERBB4GAKHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101094840-B | Quinazoline derivatives for inhibiting the growth of cancer cells and methods for preparing the same | HANMI PHARM IND CO LTD | 2012-10-31 | — | — | CN | disclosed |
| CN-101094840-A | Quinazoline derivatives for inhibiting the growth of cancer cells and methods for preparing the same | HANMI PHARM IND CO LTD (KR) | 2007-12-26 | — | — | CN | disclosed |