Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 17/20 | 0.57 |
| ▸ | BRAF | P15056 | 17/20 | 0.57 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374138 | 0.86 | RAF1 (0.70) | RAF1BRAFLCK | |
| SCHEMBL374338 | 0.82 | LCK (0.68) | RAF1BRAFLCK | |
| SCHEMBL374676 | 0.81 | LCK (0.61) | RAF1BRAFLCK | |
| SCHEMBL374367 | 0.80 | LCK (0.62) | RAF1BRAFLCK | |
| SCHEMBL374728 | 0.80 | LCK (0.65) | RAF1BRAFLCK | |
| SCHEMBL374503 | 0.80 | LCK (0.67) | RAF1BRAFLCK | |
| SCHEMBL374525 | 0.79 | LCK (0.61) | RAF1BRAFLCK | |
| SCHEMBL374523 | 0.79 | LCK (0.63) | RAF1BRAFLCK | |
| SCHEMBL374492 | 0.79 | LCK (0.70) | RAF1BRAFLCK | |
| SCHEMBL374344 | 0.78 | BRAF (0.56) | RAF1BRAFLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101035769-A | Pyrimidine urea derivatives as kinase inhibitors | NOVARTIS AG (CH) | 2007-09-12 | — | — | CN | claimed |