Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 9/20 | 0.65 |
| ▸ | RAF1 | P04049 | 1/20 | 0.65 |
| ▸ | YES1 | P07947 | 1/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27682670 | 0.93 | BRAF (0.69) | BRAFRAF1YES1MAPK14 | |
| SCHEMBL27682678 | 0.91 | MAPK14 (0.66) | BRAFRAF1YES1MAPK14 | |
| SCHEMBL27682676 | 0.90 | BRAF (0.65) | BRAFRAF1YES1MAPK14 | |
| SCHEMBL4211962 | 0.86 | MAPK14 (0.59) | BRAFRAF1YES1MAPK14 | |
| SCHEMBL27682651 | 0.85 | MAPK14 (0.62) | BRAFRAF1YES1MAPK14 | |
| SCHEMBL27701780 | 0.85 | BRAF (0.79) | BRAFRAF1YES1MAPK14 | |
| SCHEMBL4208246 | 0.84 | MAPK14 (0.57) | BRAFRAF1YES1MAPK14 | |
| SCHEMBL27682671 | 0.84 | MAPK14 (0.69) | BRAFRAF1YES1MAPK14 | |
| SCHEMBL27682842 | 0.84 | MAPK14 (0.65) | BRAFRAF1YES1MAPK14 | |
| SCHEMBL4242038 | 0.84 | BRAF (0.64) | BRAFRAF1YES1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101048388-A | Quinazolinone derivatives and their use as B-Raf inhibitors | ASTRAZENECA AB (SE) | 2007-10-03 | — | — | CN | disclosed |