Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 15/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2770535 | 1.00 | NR1H4 (0.62) | NR1H4KDM4EALDH1A1SMN1; SMN2PKM | |
| SCHEMBL2775129 | 0.93 | NR1H4 (0.59) | NR1H4KDM4EALDH1A1SMN1; SMN2PTPN11 | |
| SCHEMBL2775130 | 0.93 | NR1H4 (0.59) | NR1H4KDM4EALDH1A1SMN1; SMN2PTPN11 | |
| SCHEMBL2772894 | 0.86 | NR1H4 (0.67) | NR1H4 | |
| SCHEMBL2771079 | 0.85 | NR1H4 (0.56) | NR1H4 | |
| SCHEMBL2771082 | 0.85 | NR1H4 (0.56) | NR1H4 | |
| SCHEMBL2773817 | 0.85 | NR1H4 (0.54) | NR1H4PTPN11FFAR1 | |
| SCHEMBL2771327 | 0.85 | NR1H4 (0.55) | NR1H4 | |
| SCHEMBL2771326 | 0.85 | NR1H4 (0.55) | NR1H4 | |
| SCHEMBL2774467 | 0.84 | NR1H4 (0.57) | NR1H4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |