Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL15917025 | 1.00 | TDP1 (0.42) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL27705344 | 1.00 | TDP1 (0.42) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL7596069 | 1.00 | TDP1 (0.42) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL284735 | 0.97 | TDP1 (0.44) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL28229822 | 0.97 | TDP1 (0.44) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL1071245 | 0.93 | TDP1 (0.42) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL1071243 | 0.93 | TDP1 (0.42) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL27501486 | 0.90 | TDP1 (0.40) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL9681885 | 0.90 | TDP1 (0.40) | TDP1FFAR3LCKFYNALDH1A1 | |
| Methacrylic Acid SCHEMBL6914452 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107880091-A | Preparation, its preparation method and the application of hydrophobic therapeutic agent | 尼科斯眼药公司 | 2018-04-06 | — | — | CN | disclosed |
| CN-104350063-B | Formulations of hydrophobic therapeutic agents, methods of making and uses thereof | 尼科斯眼药公司 | 2018-01-05 | — | — | CN | disclosed |
| CN-102655856-A | Nanoparticulate olmesartan medoxomil compositions, process for the preparation thereof and pharmaceutical compositions containing them | DRUGGABILITY TECHNOLOGIES IP HOLDCO JERSEY LTD | 2012-09-05 | — | — | CN | disclosed |
| CN-101232872-A | Formulations for 7-(t-butoxy)iminomethyl camptothecin | NOVARTIS AG (CH) | 2008-07-30 | — | — | CN | disclosed |
| CN-101198314-A | Nanoparticulate quinazoline derivative formulations | ELAN PHARMA INT LTD (IE) | 2008-06-11 | — | — | CN | disclosed |
| CN-101198316-A | Nanoparticulate bisphosphonate compositions | ELAN PHARMA INT LTD (IE) | 2008-06-11 | — | — | CN | disclosed |
| CN-101175480-A | Nanoparticulate leukotriene receptor antagonist/corticosteroid formulations | ELAN PHARMA INT LTD (IE) | 2008-05-07 | — | — | CN | disclosed |
| CN-101132770-A | Nanoparticulate candesartan formulations | ELAN PHARMA INT LTD (IE) | 2008-02-27 | — | — | CN | disclosed |