Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 9/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | CHUK | O15111 | 7/20 | 0.36 |
| ▸ | IKBKG | Q9Y6K9 | 7/20 | 0.36 |
| ▸ | RAF1 | P04049 | 3/20 | 0.35 |
| ▸ | BRAF | P15056 | 3/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27688628 | 0.95 | IKBKB (0.45) | IKBKBHDAC1CHUKIKBKGRAF1 | |
| SCHEMBL27688581 | 0.92 | IKBKB (0.41) | IKBKBHDAC1CHUKIKBKGRAF1 | |
| SCHEMBL28770004 | 0.91 | IKBKB (0.39) | IKBKBCHUKIKBKGRAF1BRAF | |
| SCHEMBL27688640 | 0.90 | IKBKB (0.42) | IKBKBHDAC1CHUKIKBKGSYK | |
| SCHEMBL27688651 | 0.89 | IKBKB (0.39) | IKBKBCHUKIKBKGSYKMEN1 | |
| SCHEMBL27708383 | 0.88 | IKBKB (0.38) | IKBKBCHUKIKBKGSYKMEN1 | |
| SCHEMBL27832468 | 0.87 | IKBKB (0.35) | IKBKBHDAC1CHUKIKBKGSYK | |
| SCHEMBL28765987 | 0.87 | IKBKB (0.38) | IKBKBCHUKIKBKGSYKMEN1 | |
| SCHEMBL27688636 | 0.87 | IKBKB (0.38) | IKBKBCHUKIKBKGRAF1BRAF | |
| SCHEMBL27688661 | 0.86 | PDGFRB (0.45) | IKBKBHDAC1CHUKIKBKGSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101115749-B | Aminopyrimidine compounds and methods of use | AMGEN INC | 2011-06-22 | — | — | CN | disclosed |
| CN-101115749-A | Aminopyrimidine compounds and methods of use | AMGEN INC (US) | 2008-01-30 | — | — | CN | disclosed |