Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 16/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL56702 | 1.00 | NTRK1 (0.46) | NTRK1MAPK1JAK2JAK3AURKA | |
| SCHEMBL57581 | 0.87 | NTRK1 (0.49) | NTRK1JAK2JAK3AURKAAURKB | |
| SCHEMBL56396 | 0.84 | NTRK1 (0.53) | NTRK1JAK2JAK3AURKAAURKB | |
| SCHEMBL57021 | 0.84 | NTRK1 (0.50) | NTRK1MAPK1JAK2JAK3AURKA | |
| SCHEMBL56513 | 0.82 | JAK2 (0.52) | NTRK1JAK2JAK3AURKAAURKB | |
| SCHEMBL57014 | 0.79 | NTRK1 (0.55) | NTRK1JAK2JAK3AURKAAURKB | |
| SCHEMBL57840 | 0.78 | NTRK1 (0.59) | NTRK1MAPK1JAK2JAK3AURKA | |
| SCHEMBL57234 | 0.77 | NTRK1 (0.54) | NTRK1MAPK1JAK2JAK3AURKA | |
| SCHEMBL4698236 | 0.76 | NTRK1 (0.47) | NTRK1JAK2JAK3 | |
| SCHEMBL4693863 | 0.75 | NTRK1 (0.44) | NTRK1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101119988-A | Chemical compound | ASTRAZENECA AB (SE) | 2008-02-06 | — | — | CN | claimed |
| CN-101119988-B | Chemical compound | ASTRAZENECA AB | 2013-03-06 | — | — | CN | disclosed |