Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.47 |
| ▸ | SREBF2 | Q12772 | 4/20 | 0.41 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 9/20 | 0.36 |
| ▸ | TP53 | P04637 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL260324 | 0.83 | MAPT (0.37) | MAPTTP53LMNATHRB | |
| SCHEMBL259331 | 0.83 | CDC7 (0.45) | CDC7DBF4MAPTTP53LMNA | |
| SCHEMBL260977 | 0.81 | MAPT (0.44) | MAPTTP53LMNATHRBRXFP1 | |
| SCHEMBL259721 | 0.80 | MAPT (0.53) | MAPTTP53LMNARXFP1 | |
| SCHEMBL27953559 | 0.79 | CDC7 (0.48) | CDC7DBF4SREBF2SREBF1MAPT | |
| SCHEMBL261446 | 0.79 | MAPT (0.46) | MAPTTP53LMNATHRB | |
| SCHEMBL260042 | 0.79 | TP53 (0.49) | MAPTTP53LMNATHRBALDH1A1 | |
| SCHEMBL264075 | 0.79 | TP53 (0.35) | MAPTTP53LMNATHRBRXFP1 | |
| SCHEMBL260587 | 0.79 | MAPT (0.42) | MAPTTP53LMNATHRB | |
| SCHEMBL260722 | 0.79 | MAPT (0.54) | MAPTTP53LMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134010-B2 | 4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenylamine; N-{4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenyl}-acetamide; or4-Methyl-5-(2-nitrooxy-ethyl)-2-(4-nitro-phenyl)-thiazole; cardiovascular, gastrointestinal, inflammatory, respiratory disease | RENOPHARM LTD. (IL) | 2012-03-13 | — | — | US | disclosed |