Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 9/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.36 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL485656 | 0.82 | CXCR2 (0.54) | CXCR2KDM4EMEN1KMT2AOPRM1 | |
| SCHEMBL3926235 | 0.77 | CXCR2 (0.67) | CXCR2KDM4E | |
| SCHEMBL13712650 | 0.77 | CXCR2 (0.67) | CXCR2KDM4E | |
| SCHEMBL485138 | 0.77 | CXCR2 (0.63) | CXCR2KDM4EMEN1KMT2AMAPT | |
| SCHEMBL3936570 | 0.76 | CXCR2 (0.66) | CXCR2KDM4E | |
| SCHEMBL485239 | 0.76 | KDM4E (0.63) | CXCR2KDM4EMEN1KMT2AGAA | |
| SCHEMBL13712649 | 0.75 | CXCR2 (0.52) | CXCR2KDM4EMEN1KMT2A | |
| SCHEMBL3928468 | 0.75 | CXCR2 (0.55) | CXCR2KDM4E | |
| SCHEMBL485731 | 0.73 | CXCR2 (0.53) | CXCR2KDM4EMEN1KMT2A | |
| SCHEMBL10289511 | 0.71 | CXCR2 (0.53) | CXCR2KDM4EPLK1ERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101094830-A | Fused bicyclic carboxamide derivatives for use as CXCR2 inhibitors in the treatment of inflammation | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-26 | — | — | CN | claimed |