Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 18/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 16/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 13/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 10/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 10/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 10/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27715233 | 0.90 | HDAC1 (0.44) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL5117982 | 0.86 | HDAC1 (0.42) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL28315016 | 0.85 | HDAC1 (0.42) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL27695446 | 0.85 | HDAC1 (0.43) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL27695257 | 0.84 | HDAC1 (0.40) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL28316199 | 0.84 | HDAC1 (0.40) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL27695314 | 0.82 | HDAC1 (0.41) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL27715211 | 0.82 | HDAC1 (0.39) | HDAC1HDAC3HDAC2HDAC8HDAC6 | |
| SCHEMBL27715161 | 0.78 | HDAC3 (0.43) | HDAC1HDAC3HDAC2HDAC8CYP2C9 | |
| SCHEMBL15477812 | 0.76 | HDAC1 (0.50) | HDAC1HDAC3HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101107220-A | Amide derivatives as inhibitors of histone deacetylase | ANGELETTI P INST RICHERCHE BIO (IT) | 2008-01-16 | — | — | CN | disclosed |