Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2950114 | 0.84 | HRH3 (0.73) | HRH3ROCK2CYP3A4SYKMEN1 | |
| SCHEMBL2951205 | 0.83 | HRH3 (0.67) | HRH3ROCK2CYP3A4SYKMEN1 | |
| SCHEMBL2943709 | 0.82 | HRH3 (0.66) | HRH3MEN1KMT2A | |
| SCHEMBL2952637 | 0.80 | HRH3 (0.66) | HRH3ROCK2CYP3A4SYKMEN1 | |
| SCHEMBL2952603 | 0.80 | HRH3 (0.83) | HRH3SYKMEN1KMT2A | |
| SCHEMBL2952638 | 0.79 | HRH3 (0.67) | HRH3ROCK2CYP3A4SYKMEN1 | |
| SCHEMBL27760291 | 0.79 | HRH4 (0.47) | HRH3SYKMEN1KMT2ATLR9 | |
| SCHEMBL2947010 | 0.79 | HRH3 (0.82) | HRH3SYKMEN1KMT2A | |
| SCHEMBL2951314 | 0.78 | HRH3 (0.64) | HRH3ROCK2CYP3A4SYKMEN1 | |
| SCHEMBL2943726 | 0.78 | HRH3 (0.79) | HRH3SYKMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101107227-B | 5-aminoindole derivatives | HOFFMANN LA ROCHE | 2010-09-22 | — | — | CN | claimed |
| CN-101107227-A | 5-aminoindole derivatives | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | CN | claimed |
| CN-101107227-B | 5-aminoindole derivatives | HOFFMANN LA ROCHE | 2010-09-22 | — | — | CN | disclosed |
| CN-101107227-A | 5-aminoindole derivatives | HOFFMANN LA ROCHE (CH) | 2008-01-16 | — | — | CN | disclosed |