Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PPID | Q08752 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16532120 | 0.78 | GSK3A (0.44) | MAPK1TSHRHSD17B10ALDH1A1KDM4E | |
| SCHEMBL12684917 | 0.77 | MAPK1 (0.44) | MAPK14MAPK1NPSR1MEN1KMT2A | |
| SCHEMBL4138280 | 0.77 | MAPK1 (0.39) | MAPK1NPSR1MEN1KMT2AGAA | |
| SCHEMBL9877233 | 0.74 | MEN1 (0.56) | MEN1KMT2AGAATSHRALDH1A1 | |
| SCHEMBL1386186 | 0.72 | MAPK14 (0.55) | MAPK14MEN1KMT2AGAAHSD17B10 | |
| SCHEMBL16532144 | 0.72 | HSD17B10 (0.39) | MAPK1TSHRHSD17B10ALDH1A1HPGD | |
| SCHEMBL2145771 | 0.72 | BRAF (0.48) | MAPK14MAPK1MEN1KMT2A | |
| SCHEMBL9877113 | 0.72 | GAA (0.52) | MAPK14MAPK1NPSR1MEN1KMT2A | |
| SCHEMBL22057237 | 0.72 | NPSR1 (0.40) | MAPK14MAPK1NPSR1HSD17B10ALDH1A1 | |
| SCHEMBL13163211 | 0.72 | MEN1 (0.51) | MAPK14MAPK1NPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101282960-A | RAF inhibitor compounds and methods | GENENTECH INC (US) | 2008-10-08 | — | — | CN | disclosed |