Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10224193 | 0.86 | KDM4E (0.62) | KDM4ETSHRNPSR1MAPK1CYP1A2 | |
| SCHEMBL27708855 | 0.85 | KDM4E (0.53) | KDM4ETSHRALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL27491785 | 0.84 | KDM4E (0.46) | KDM4ETSHRNPSR1MAPK1CYP1A2 | |
| SCHEMBL24233057 | 0.82 | KDM4E (0.57) | KDM4ETSHRNPSR1MAPK1CYP1A2 | |
| SCHEMBL20715700 | 0.81 | KDM4E (0.46) | KDM4ETSHRNPSR1MAPK1CYP1A2 | |
| SCHEMBL20032326 | 0.80 | KDM4E (0.48) | KDM4ETSHRNPSR1MAPK1CYP1A2 | |
| SCHEMBL15723552 | 0.80 | MAPK1 (0.58) | KDM4ETSHRNPSR1MAPK1CYP1A2 | |
| SCHEMBL24713308 | 0.80 | KDM4E (0.44) | KDM4ETSHRNPSR1MAPK1CYP1A2 | |
| SCHEMBL7263660 | 0.79 | TRIM24 (0.43) | KDM4ETSHRMAPK1LMNA | |
| SCHEMBL28069498 | 0.79 | ACACB (0.40) | KDM4EMEN1KMT2ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102333769-B | Derivatives of 2-pyridin-2-yl-pyrazol-3 (2H) -one, preparation thereof, and therapeutic use as HIF activators | SANOFI AVENTIS | 2014-08-27 | — | — | CN | disclosed |
| CN-102333769-A | Derivatives of 2-pyridin-2-yl-pyrazol-3 (2H) -one, preparation thereof, and therapeutic use as HIF activators | SANOFI AVENTIS | 2012-01-25 | — | — | CN | disclosed |
| CN-101151246-B | 1-benzylindole-2-carboxamide derivatives | ORGANON NV | 2011-04-13 | — | — | CN | disclosed |
| CN-101151246-A | 1-benzylindole-2-carboxamide derivatives | ORGANON NV (NL) | 2008-03-26 | — | — | CN | disclosed |