Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 8/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.68 |
| ▸ | BRAF | P15056 | 3/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | JAK2 | O60674 | 1/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.68 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.68 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.68 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.68 |
| ▸ | BTK | Q06187 | 5/20 | 0.66 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.60 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.60 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.60 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.60 |
| ▸ | LCK | P06239 | 5/20 | 0.58 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27720383 | 0.96 | CSF1R (0.66) | CSF1RMAPK14BRAFCYP2C9JAK2 | |
| SCHEMBL27720381 | 0.89 | BTK (0.83) | CSF1RMAPK14BRAFCYP2C9BTK | |
| SCHEMBL3933304 | 0.88 | MAPK14 (0.72) | CSF1RMAPK14BRAFCYP2C9JAK2 | |
| SCHEMBL28768581 | 0.85 | BTK (0.77) | CSF1RMAPK14BRAFCYP2C9BTK | |
| SCHEMBL3935933 | 0.84 | CSF1R (0.66) | CSF1RMAPK14BRAFCYP2C9JAK2 | |
| SCHEMBL3932964 | 0.84 | CSF1R (0.74) | CSF1RMAPK14BRAFCYP2C9JAK2 | |
| SCHEMBL3933086 | 0.84 | CSF1R (0.80) | CSF1RMAPK14BRAFCYP2C9JAK2 | |
| SCHEMBL14286496 | 0.82 | CSF1R (0.75) | CSF1RMAPK14BRAFCYP2C9JAK2 | |
| SCHEMBL2494570 | 0.82 | CSF1R (0.81) | CSF1RMAPK14BRAFCYP2C9JAK2 | |
| SCHEMBL27749035 | 0.82 | CSF1R (0.73) | CSF1RMAPK14BRAFCYP2C9JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |