Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.76 |
| ▸ | BTK | Q06187 | 11/20 | 0.75 |
| ▸ | LCK | P06239 | 10/20 | 0.75 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.75 |
| ▸ | KDR | P35968 | 3/20 | 0.75 |
| ▸ | KIT | P10721 | 3/20 | 0.73 |
| ▸ | CSF1R | P07333 | 2/20 | 0.72 |
| ▸ | ABL1 | P00519 | 1/20 | 0.71 |
| ▸ | SRC | P12931 | 1/20 | 0.71 |
| ▸ | BLK | P51451 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3929980 | 0.89 | BTK (0.79) | BRAFCYP2C9BTKLCKMAPK14 | |
| SCHEMBL27720381 | 0.89 | BTK (0.83) | BRAFCYP2C9BTKLCKMAPK14 | |
| SCHEMBL3939130 | 0.88 | BTK (0.70) | BRAFCYP2C9BTKLCKMAPK14 | |
| SCHEMBL28768581 | 0.87 | BTK (0.77) | BRAFCYP2C9BTKLCKMAPK14 | |
| SCHEMBL3929867 | 0.87 | BRAF (1.00) | BRAFCYP2C9BTKLCKMAPK14 | |
| SCHEMBL2944882 | 0.86 | LCK (1.00) | BRAFCYP2C9BTKLCKMAPK14 | |
| SCHEMBL3934754 | 0.85 | LCK (0.79) | BRAFCYP2C9BTKLCKMAPK14 | |
| SCHEMBL2950585 | 0.84 | KDR (1.00) | BRAFCYP2C9BTKLCKMAPK14 | |
| SCHEMBL1276318 | 0.84 | BRAF (1.00) | BRAFBTKLCKMAPK14KDR | |
| SCHEMBL2947918 | 0.83 | LCK (1.00) | BRAFCYP2C9BTKLCKMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |