Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.59 |
| ▸ | MTOR | P42345 | 12/20 | 0.59 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2773798 | 0.90 | PIK3CA (0.61) | PIK3CAMTORTP53MAPT | |
| SCHEMBL751215 | 0.89 | PIK3CA (0.58) | PIK3CAMTORTP53MAPTTRPV4 | |
| SCHEMBL11025368 | 0.88 | PIK3CA (0.75) | PIK3CAMTORTP53MAPT | |
| SCHEMBL11031708 | 0.88 | PIK3CA (0.56) | PIK3CAMTORTP53MAPT | |
| SCHEMBL11024686 | 0.88 | PIK3CA (0.72) | PIK3CAMTOR | |
| SCHEMBL2772495 | 0.88 | PIK3CA (0.57) | PIK3CAMTORMAP3K12 | |
| SCHEMBL754608 | 0.86 | PIK3CA (0.55) | PIK3CAMTOR | |
| SCHEMBL2788748 | 0.85 | PIK3CA (0.54) | PIK3CAMTOR | |
| SCHEMBL2776327 | 0.85 | PIK3CA (0.71) | PIK3CAMTOR | |
| SCHEMBL2771543 | 0.84 | PIK3CA (0.69) | PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | claimed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | claimed |
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | disclosed |