SCHEMBL27727445

SCHEMBL27727445

C=CC(N1CCN(C)CC1)S(=O)(=O)c1ccc(C(CC2CCCC2)C(=O)Nc2ccc(C(=O)O)cn2)cc1

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 18/20 0.45
KCNH2 Q12809 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3566516 0.85 GCK (0.56) GCKKCNH2
SCHEMBL3563017 0.85 GCK (0.56) GCKKCNH2
SCHEMBL27727416 0.85 GCK (0.43) GCKKCNH2
SCHEMBL27748425 0.82 GCK (0.57) GCK
SCHEMBL27727394 0.82 GCK (0.67) GCKKCNH2
SCHEMBL27727474 0.82 GCK (0.53) GCK
SCHEMBL27727388 0.82 GCK (0.49) GCK
SCHEMBL28764307 0.82 GCK (0.40) GCK
SCHEMBL27727496 0.81 GCK (0.51) GCKKCNH2
SCHEMBL2645847 0.81 GCK (0.61) GCKKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101273015-A 3-cyclyl-2- (4-sulfamo yl-phenyl) -N-cyclyl-propionamide derivatives useful in the treatment of impaired glucose tolerance and diabetes NOVARTIS AG (CH) 2008-09-24 CN claimed
CN-101273015-A 3-cyclyl-2- (4-sulfamo yl-phenyl) -N-cyclyl-propionamide derivatives useful in the treatment of impaired glucose tolerance and diabetes NOVARTIS AG (CH) 2008-09-24 CN disclosed