Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.44 |
| ▸ | OGA | O60502 | 3/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27728075 | 0.86 | OGA (0.44) | TLR8OGAACACB | |
| SCHEMBL1743852 | 0.83 | HRH3 (0.57) | HRH3TLR9TLR8TLR7OGA | |
| SCHEMBL1743345 | 0.83 | HRH3 (0.57) | HRH3TLR9TLR8TLR7OGA | |
| SCHEMBL27921240 | 0.82 | TLR9 (0.44) | HRH3TLR9TLR8TLR7OGA | |
| SCHEMBL27707230 | 0.81 | NPC1 (0.46) | HRH3 | |
| SCHEMBL27676516 | 0.80 | HRH3 (0.47) | HRH3OGA | |
| SCHEMBL1744098 | 0.80 | HRH3 (0.60) | HRH3TLR9TLR8TLR7 | |
| SCHEMBL1743029 | 0.80 | KDM4E (0.54) | HRH3ACACB | |
| SCHEMBL1742758 | 0.80 | TLR9 (0.52) | HRH3TLR9TLR8TLR7OGA | |
| SCHEMBL1744089 | 0.80 | CNR2 (0.49) | HRH3TLR9TLR8TLR7OGA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103110635-A | Histamine H3 receptor antagonist | NOVO NORDISK AS | 2013-05-22 | — | — | CN | disclosed |
| CN-101218206-A | Histamine H3 receptor antagonists | NOVO NORDISK AS (DK) | 2008-07-09 | — | — | CN | disclosed |