Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.82 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.82 |
| ▸ | MAP3K8 | P41279 | 4/20 | 0.71 |
| ▸ | SRC | P12931 | 6/20 | 0.66 |
| ▸ | MAP2K1 | Q02750 | 8/20 | 0.65 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.65 |
| ▸ | PRKCG | P05129 | 1/20 | 0.65 |
| ▸ | PRKCB | P05771 | 1/20 | 0.65 |
| ▸ | PRKCA | P17252 | 1/20 | 0.65 |
| ▸ | PRKCH | P24723 | 1/20 | 0.65 |
| ▸ | PRKCI | P41743 | 1/20 | 0.65 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.65 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.65 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.65 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.65 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.65 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.65 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6383141 | 0.90 | EGFR (1.00) | EGFRERBB2SRCMAP2K1FYN | |
| SCHEMBL2023939 | 0.85 | EGFR (0.69) | EGFRERBB2MAP3K8SRC | |
| SCHEMBL1894502 | 0.84 | MAP3K8 (0.65) | EGFRERBB2MAP3K8SRCMAP2K1 | |
| Hydrochloric Acid SCHEMBL13505731 | 0.84 | EGFR (0.68) | EGFRERBB2MAP3K8SRC | |
| SCHEMBL3600034 | 0.83 | EGFR (0.72) | EGFRERBB2SRC | |
| SCHEMBL6070984 | 0.83 | MAP3K8 (1.00) | EGFRERBB2MAP3K8SRCMAP2K1 | |
| SCHEMBL6070981 | 0.83 | MAP3K8 (0.73) | EGFRERBB2MAP3K8SRCMAP2K1 | |
| SCHEMBL2963866 | 0.83 | EGFR (0.80) | EGFRERBB2SRCMAP2K1PRKD3 | |
| SCHEMBL1892908 | 0.83 | EGFR (0.79) | EGFRERBB2MAP3K8SRCMAP2K1 | |
| SCHEMBL5251901 | 0.82 | EGFR (0.83) | EGFRERBB2MAP3K8SRCMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101223143-A | 3-cyanoquinoline inhibitors of TPL2 kinase and methods of making and using the same | WYETH CORP (US) | 2008-07-16 | — | — | CN | disclosed |