Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 3/20 | 0.61 |
| ▸ | MAP3K8 | P41279 | 11/20 | 0.60 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.43 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27707287 | 0.90 | SRC (0.75) | SRCMAP3K8DYRK1ADYRK1BEGFR | |
| SCHEMBL4963365 | 0.89 | SRC (0.77) | SRCMAP3K8DYRK1ADYRK1BEGFR | |
| SCHEMBL4960895 | 0.89 | MAP3K8 (0.62) | SRCMAP3K8DYRK1ADYRK1BEGFR | |
| SCHEMBL27707397 | 0.88 | SRC (0.55) | SRCMAP3K8PRKCQDYRK1ADYRK1B | |
| SCHEMBL27728200 | 0.86 | MAP3K8 (0.61) | SRCMAP3K8DYRK1ADYRK1BEGFR | |
| SCHEMBL27707399 | 0.86 | SRC (0.53) | SRCMAP3K8DYRK1ADYRK1B | |
| SCHEMBL4961427 | 0.85 | MAP3K8 (0.63) | SRCMAP3K8DYRK1ADYRK1BEGFR | |
| SCHEMBL4963177 | 0.85 | SRC (0.54) | SRCMAP3K8DYRK1ADYRK1B | |
| SCHEMBL27707426 | 0.84 | MAP3K8 (0.65) | SRCMAP3K8DYRK1ADYRK1BEGFR | |
| SCHEMBL4960960 | 0.83 | MAP3K8 (0.64) | SRCMAP3K8DYRK1ADYRK1BEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101223143-A | 3-cyanoquinoline inhibitors of TPL2 kinase and methods of making and using the same | WYETH CORP (US) | 2008-07-16 | — | — | CN | disclosed |