Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 18/20 | 0.72 |
| ▸ | EGFR | P00533 | 4/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4076780 | 0.98 | ERBB2 (0.73) | ERBB2EGFRKCNH2ERBB4 | |
| SCHEMBL3376303 | 0.89 | ERBB2 (0.77) | ERBB2EGFRKCNH2ERBB4 | |
| SCHEMBL4080217 | 0.88 | ERBB2 (0.81) | ERBB2EGFRKCNH2ERBB4 | |
| SCHEMBL4083330 | 0.87 | ERBB2 (0.76) | ERBB2EGFRKCNH2ERBB4 | |
| SCHEMBL4083320 | 0.87 | ERBB2 (0.76) | ERBB2EGFRKCNH2ERBB4 | |
| SCHEMBL3376323 | 0.87 | ERBB2 (0.81) | ERBB2EGFRKCNH2ERBB4 | |
| SCHEMBL27709279 | 0.86 | ERBB2 (0.54) | ERBB2EGFRKCNH2ERBB4 | |
| SCHEMBL4072543 | 0.85 | ERBB2 (0.71) | ERBB2EGFRKCNH2 | |
| SCHEMBL3377576 | 0.85 | ERBB2 (0.75) | ERBB2EGFRKCNH2ERBB4 | |
| SCHEMBL5057307 | 0.85 | ERBB2 (0.78) | ERBB2EGFRKCNH2ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101208331-A | Quinazoline derivatives as inhibitors of EGF and/or ERBB2 tyrosine kinases | ASTRAZENECA AB (SE) | 2008-06-25 | — | — | CN | disclosed |