Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.65 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10374835 | 0.98 | HRH3 (0.64) | HRH3HDAC1HDAC8HDAC6HRH4 | |
| Hydrochloric Acid SCHEMBL10372662 | 0.98 | HRH3 (0.64) | HRH3HDAC1HDAC8HDAC6HRH4 | |
| Hydrochloric Acid SCHEMBL2771525 | 0.96 | HDAC1 (0.65) | HRH3HDAC1HDAC8HDAC6HRH4 | |
| SCHEMBL3275253 | 0.87 | HRH3 (0.69) | HRH3HDAC1HDAC8HDAC6HRH4 | |
| SCHEMBL28784579 | 0.87 | HRH3 (0.69) | HRH3HDAC1HDAC8HDAC6HRH4 | |
| SCHEMBL27854081 | 0.85 | HRH3 (0.67) | HRH3HDAC1HDAC8HDAC6HRH4 | |
| SCHEMBL2986364 | 0.85 | HRH3 (0.67) | HRH3HDAC1HDAC8HDAC6HRH4 | |
| Hydrochloric Acid SCHEMBL27789104 | 0.85 | HRH3 (0.67) | HRH3HDAC1HDAC8HDAC6HRH4 | |
| SCHEMBL2741682 | 0.85 | HRH3 (0.67) | HRH3HDAC1HDAC8HDAC6HRH4 | |
| SCHEMBL3275430 | 0.85 | HDAC1 (0.69) | HRH3HDAC1HDAC8HDAC6HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120238565-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS | MERCK SERONO SA (CH) | 2012-09-20 | — | — | US | disclosed |
| US-8263595-B2 | Triazolopyridine compounds and their use as ask inhibitors | MERCK SERONO SA (CH) | 2012-09-11 | — | — | US | disclosed |
| CN-101878212-A | Triazolopyridine compounds and their use as ask inhibitors | SERONO LAB | 2010-11-03 | — | — | CN | disclosed |
| US-20100197681-A1 | Triazolopyridine Compounds and Their Use as Ask Inhibitors | MERCK SERONO SA (CH) | 2010-08-05 | — | — | US | disclosed |
| EP-2181112-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS | Merck Serono S.A. (CH) | 2010-05-05 | — | — | EP | disclosed |
| WO-2009027283-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS | MERCK SERONO S.A. (CH) | 2009-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197681-A1 | Triazolopyridine Compounds and Their Use as Ask Inhibitors | MAP3K5, MAPKAPK5, MAP3K9 | HRH3 2386/4885HDAC1 1757/4885HDAC8 1273/4885 |
| US-20120238565-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS | MAP3K5, MAPKAPK5, MAP3K9 | HRH3 2386/4885HDAC1 1757/4885HDAC8 1273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.