Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.56 |
| ▸ | MTOR | P42345 | 12/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL754194 | 0.91 | PIK3CA (0.55) | PIK3CAMTORMAPTTP53LMNA | |
| SCHEMBL756343 | 0.90 | PIK3CA (0.60) | PIK3CAMTORMAPTTP53LMNA | |
| SCHEMBL2773798 | 0.89 | PIK3CA (0.61) | PIK3CAMTORMAPTTP53LMNA | |
| SCHEMBL2772795 | 0.88 | PIK3CA (0.72) | PIK3CAMTORMAPTTP53LMNA | |
| SCHEMBL2771543 | 0.85 | PIK3CA (0.69) | PIK3CAMTOR | |
| SCHEMBL11031708 | 0.85 | PIK3CA (0.56) | PIK3CAMTORMAPTTP53ABCG2 | |
| SCHEMBL749520 | 0.85 | PIK3CA (0.52) | PIK3CAMTORMAPTTP53 | |
| SCHEMBL754608 | 0.84 | PIK3CA (0.55) | PIK3CAMTORMAPK13MAPK12MAPK11 | |
| SCHEMBL2776327 | 0.84 | PIK3CA (0.71) | PIK3CAMTOR | |
| SCHEMBL2772495 | 0.83 | PIK3CA (0.57) | PIK3CAMTORMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | claimed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | claimed |
| EP-2430013-B1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC (US) | 2014-10-15 | — | — | EP | disclosed |