Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 13/20 | 0.66 |
| ▸ | NR1H3 | Q13133 | 13/20 | 0.66 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | RXRA | P19793 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 4/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28774581 | 0.89 | NR1H2 (0.61) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL27710163 | 0.88 | NR1H2 (0.55) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407876 | 0.87 | NR1H2 (0.75) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL3867717 | 0.87 | NR1H2 (0.66) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407782 | 0.86 | NR1H2 (0.73) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL3864218 | 0.86 | NR1H2 (0.64) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407495 | 0.86 | NR1H2 (0.64) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL3860036 | 0.85 | NR1H2 (0.66) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL3862021 | 0.85 | NR1H2 (0.62) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407279 | 0.84 | NR1H2 (0.58) | NR1H2NR1H3NR1I2NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101213194-A | Indazoles useful in treating cardiovascular diseases | WYETH CORP (US) | 2008-07-02 | — | — | CN | claimed |
| CN-101213194-A | Indazoles useful in treating cardiovascular diseases | WYETH CORP (US) | 2008-07-02 | — | — | CN | disclosed |