Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 17/20 | 0.60 |
| ▸ | NR1H3 | Q13133 | 17/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.40 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.40 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27710169 | 0.94 | NR1H2 (0.59) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407227 | 0.91 | NR1H2 (0.62) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1408283 | 0.89 | NR1H2 (0.59) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407379 | 0.88 | NR1H2 (0.58) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407921 | 0.87 | NR1H2 (0.56) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407442 | 0.86 | NR1H2 (0.77) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL27710198 | 0.86 | NR1H2 (0.62) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL27730694 | 0.86 | NR1H2 (0.57) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1408029 | 0.85 | NR1H2 (0.61) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407889 | 0.85 | NR1H2 (0.66) | NR1H2NR1H3NR1I2NR3C1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101213194-A | Indazoles useful in treating cardiovascular diseases | WYETH CORP (US) | 2008-07-02 | — | — | CN | claimed |
| CN-101213194-A | Indazoles useful in treating cardiovascular diseases | WYETH CORP (US) | 2008-07-02 | — | — | CN | disclosed |