Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 13/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2771077 | 0.90 | NR1H4 (0.55) | NR1H4FFAR1 | |
| SCHEMBL2771697 | 0.87 | NR1H4 (0.63) | NR1H4MRGPRX4 | |
| SCHEMBL2772894 | 0.87 | NR1H4 (0.67) | NR1H4MRGPRX4 | |
| SCHEMBL2774467 | 0.86 | NR1H4 (0.57) | NR1H4FFAR1 | |
| SCHEMBL2773272 | 0.86 | NR1H4 (0.57) | NR1H4FFAR1 | |
| SCHEMBL2770495 | 0.85 | NR1H4 (0.67) | NR1H4MRGPRX4 | |
| SCHEMBL2773870 | 0.84 | NR1H4 (0.55) | NR1H4FFAR1 | |
| SCHEMBL3768002 | 0.84 | NR1H4 (0.54) | NR1H4 | |
| SCHEMBL2773817 | 0.84 | NR1H4 (0.54) | NR1H4FFAR1 | |
| SCHEMBL2772118 | 0.83 | NR1H4 (0.54) | NR1H4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |