Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.47 |
| ▸ | PPARA | Q07869 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | GCK | P35557 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2769706 | 0.93 | NR1H4 (0.50) | NR1H4PPARASMN1; SMN2MAOBMRGPRX4 | |
| SCHEMBL2770618 | 0.91 | NR1H4 (0.58) | NR1H4PPARASMN1; SMN2KDM4EMRGPRX4 | |
| SCHEMBL2772424 | 0.85 | NR1H4 (0.40) | NR1H4PPARASMN1; SMN2MAOBKDM4E | |
| SCHEMBL2773169 | 0.84 | NR1H4 (0.48) | NR1H4PPARAMRGPRX4MAPK14RXRA | |
| SCHEMBL2772215 | 0.84 | NR1H4 (0.56) | NR1H4PPARAMRGPRX4KMT2A | |
| SCHEMBL2771176 | 0.84 | NR1H4 (0.61) | NR1H4PPARASMN1; SMN2MRGPRX4 | |
| SCHEMBL2772284 | 0.84 | NR1H4 (0.51) | NR1H4MRGPRX4MAPK14RXRARXRB | |
| SCHEMBL2770116 | 0.84 | KDM4E (0.40) | NR1H4PPARASMN1; SMN2MAOBKDM4E | |
| SCHEMBL2771059 | 0.81 | NR1H4 (0.57) | NR1H4PPARAMAOBMRGPRX4MAPK14 | |
| SCHEMBL2771368 | 0.81 | NR1H4 (0.59) | NR1H4PPARAMRGPRX4GCKNR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |