Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 14/20 | 0.55 |
| ▸ | EGFR | P00533 | 10/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.55 |
| ▸ | SRC | P12931 | 5/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.52 |
| ▸ | PRKDC | P78527 | 3/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | HCK | P08631 | 2/20 | 0.52 |
| ▸ | MTOR | P42345 | 2/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 3/20 | 0.48 |
| ▸ | TEK | Q02763 | 3/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2960030 | 0.91 | IGF1R (0.57) | IGF1REGFRERBB2SRCKDR | |
| SCHEMBL2966182 | 0.91 | SRC (0.56) | IGF1REGFRERBB2SRCKDR | |
| SCHEMBL2959607 | 0.89 | IGF1R (0.54) | IGF1REGFRERBB2SRCKDR | |
| SCHEMBL2956132 | 0.89 | IGF1R (0.54) | IGF1REGFRERBB2SRCKDR | |
| SCHEMBL2956130 | 0.89 | IGF1R (0.54) | IGF1REGFRERBB2SRCKDR | |
| SCHEMBL2966218 | 0.89 | SRC (0.57) | IGF1REGFRERBB2SRCKDR | |
| SCHEMBL2953983 | 0.89 | IGF1R (0.66) | IGF1REGFRERBB2KDR | |
| SCHEMBL2953982 | 0.89 | IGF1R (0.66) | IGF1REGFRERBB2KDR | |
| SCHEMBL2961198 | 0.89 | EGFR (0.56) | IGF1REGFRERBB2SRCKDR | |
| SCHEMBL2960266 | 0.89 | IGF1R (0.56) | IGF1REGFRERBB2SRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101389630-A | Protein kinase inhibitors | ABBOTT LAB (US) | 2009-03-18 | — | — | CN | disclosed |