Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.36 |
| ▸ | ERG | P11308 | 2/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | APAF1 | O14727 | 6/20 | 0.35 |
| ▸ | GAA | P10253 | 6/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 5/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 5/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.35 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2774430 | 0.91 | MAPT (0.40) | HRH4MAPTAPAF1GAASENP7 | |
| SCHEMBL2771590 | 0.90 | HRH4 (0.38) | HRH4ESR1ESR2FPR2MAPT | |
| SCHEMBL2774620 | 0.89 | HRH4 (0.38) | HRH4ESR1ESR2MAPTAPAF1 | |
| SCHEMBL2773159 | 0.88 | MAPT (0.35) | HRH4MAPTAPAF1GAASENP7 | |
| SCHEMBL2772675 | 0.88 | GAA (0.46) | HRH4MAPTAPAF1GAASENP7 | |
| SCHEMBL2771555 | 0.88 | MAPT (0.47) | HRH4MAPTAPAF1GAASENP7 | |
| SCHEMBL2771103 | 0.88 | HRH4 (0.38) | HRH4ESR1ESR2MAPTAPAF1 | |
| SCHEMBL2770979 | 0.86 | HRH4 (0.38) | HRH4MAPTAPAF1GAASENP7 | |
| SCHEMBL2772066 | 0.86 | MAPT (0.49) | HRH4MAPTAPAF1GAASENP7 | |
| SCHEMBL2772831 | 0.86 | GALR2 (0.41) | HRH4MAPTAPAF1GAASENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137275-A1 | TRIAMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF CDC25 PHOSPHATASE | IPSEN PHARMA S.A.S. (FR) | 2010-06-03 | — | — | US | claimed |
| EP-2152675-A1 | TRIAMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF CDC25 PHOSPHATASE | IPSEN PHARMA S.A.S. (FR) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008152223-A1 | TRIAMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF CDC25 PHOSPHATASE | IPSEN PHARMA S.A.S. (FR) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137275-A1 | TRIAMINOPYRIMIDINE DERIVATIVES AS INHIBITORS OF CDC25 PHOSPHATASE | CDC25A, CDC25B, CDC25C | HRH4 2711/4885ESR1 3630/4885ESR2 3278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.