Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 19/20 | 0.73 |
| ▸ | AURKB | Q96GD4 | 19/20 | 0.73 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.62 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | CIT | O14578 | 1/20 | 0.62 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.62 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | FLT1 | P17948 | 1/20 | 0.62 |
| ▸ | FECH | P22830 | 1/20 | 0.62 |
| ▸ | DCK | P27707 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27735462 | 0.93 | AURKA (0.74) | AURKAAURKBINCENPTPX2PLK4 | |
| SCHEMBL4311285 | 0.86 | AURKA (0.75) | AURKAAURKBINCENPTPX2PLK4 | |
| SCHEMBL4313211 | 0.84 | AURKB (0.88) | AURKAAURKBINCENPTPX2PLK4 | |
| SCHEMBL4310001 | 0.84 | AURKB (1.00) | AURKAAURKBINCENPTPX2PLK4 | |
| SCHEMBL4308858 | 0.83 | AURKA (1.00) | AURKAAURKBINCENPTPX2PLK4 | |
| SCHEMBL4307141 | 0.83 | AURKA (1.00) | AURKAAURKBINCENPTPX2PLK4 | |
| SCHEMBL5135668 | 0.83 | AURKA (0.77) | AURKAAURKBINCENPTPX2PLK4 | |
| SCHEMBL14160547 | 0.81 | AURKA (0.69) | AURKAAURKBINCENPTPX2PLK4 | |
| SCHEMBL14160612 | 0.79 | AURKA (0.90) | AURKAAURKBINCENPTPX2PLK4 | |
| SCHEMBL4310369 | 0.79 | AURKA (0.66) | AURKAAURKBINCENPTPX2PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101389324-A | Azaindole inhibitors of aurora kinases | SMITHKLINE BEECHAM CORP (US) | 2009-03-18 | — | — | CN | claimed |
| CN-101389324-A | Azaindole inhibitors of aurora kinases | SMITHKLINE BEECHAM CORP (US) | 2009-03-18 | — | — | CN | disclosed |